Correlation of A G to A Nucleotide Substitution in Upstream Region of Leptin with Breast Cancer Susceptibility Arab-Yarmohammadi Vahid1, Sharifi Mehran2 1Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran 2Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran Online published on 7 May, 2019. Abstract Single nucleotide polymorphisms in leptin gene may increase the risk of breast cancer. The aim of this study was to investigate the association of leptin G-2548A gene polymorphism with breast cancer risk in an Iranian population. In a case-control study, 98 subjects including 45 women with breast cancer and 53 healthy women were recruited. The genotypes of G-2548A polymorphism were detected by polymerase chain reaction-restriction fragment length polymorphism. Our data revealed that there is a significant association between AG homozygote genotype and breast cancer risk (OR= 2.41, 95%CI= 1.05–5.52, p= 0.037). Also, we observed that G allele marginally increases the breast cancer risk (OR= 1.92, 95%CI= 1.00–3.70, p= 0.049). Based on our preliminary study, leptin G-2548A gene polymorphism may be a genetic risk factor for breast cancer and further studies with larger sample size are required to obtain more accurate results. Top Keywords Breast cancerLeptin gene, G-2548A variety. Top |