Vitamin C Protect Against Monosodium Glutamate Mediated Oxidative Stress in the Male White Rats Nasir Afyaa Sabah Department of Ecology, Faculty of Science, University of Kufa, Najaf, Iraq Online published on 17 July, 2019. Abstract The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by monosodium glutamate. Total number of twenty male rats were divided into five groups each group contain four rats. Groups I administrated distal water and standard diet to keep as control group, group II and III were administered MSG in to two doses (8, 16g/kg) respectively. Finally, Group IV and V were administrated MSG (8, 16 g/kg with vitamin C) respectively for 30 days. The results show decrease in serum triiodothyronine, serum thyroxine, superoxide dismutase, catalase in addition significant increment in the thyroid stimulating hormone level and lipid peroxidation in the groups of rats treated with MSG only while all parameters back in to normal values in the groups of rats treated with MSG and vitamin C also, the histopathological changes appear degeneration and pyknotic cells in the thyroid gland. In conclusion, food additives as MSG have many side effects in the body when taken it for long period and vitamin C has vital role to protect the body from any foreign body. Top Keywords Vitamin C, MSG, SOD, CAT, MDA, thyroid gland. Top |