Co-Molecular Roles of Human Cytomegalovirus and p73 gene in late events of Nasopharyngeal and Sinonasal carncinogenesis Ali Marwa Mohammed1,*, Mahmood Majid Mohammed1, Ali Saad Hasan Mohammed2 1Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq 2Communicable Diseases Research Unit, Medical College, University of Baghdad, Baghdad, Iraq *Corresponding author: Marwa Mohammed Ali, Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq, E-mail: Majidmahmood93@yahoo.com
Online published on 17 July, 2019. Abstract Sinonasal and Nasopharyngeal carcinomas are related to many environmental and genetic predisposing factors. HCMV plays an “oncomodulatory” role in the neoplastic process and can induce cellular responses that would provide a growth advantage for neoplastic cells. p73 was implicated in carcinogenesis of nasopharyngeal and sinonasal carcinomas. The research aimed to evaluate the cellular protein expressions of P73-tumor suppressor gene in relation to HCMV infection in tissues from nasopharyngeal, sinonasal benign and malignant tumors. This study included 183 formalin fixed, paraffin embedded tissue blocks from 35 inflammatory nasal polyps (INP), 35 sinonasal papilloma (SNP), 65 nasopharyngeal carcinomas (NPC), 18 sinonasal carcinomas (SNC) as well as 30 nasal healthy tissues as control for this study. In nasopharyngeal and sinonasal cancer tissues HCMV-DNA were detected in (78.5% and 66.7%, respectively) while, in sinonasal papilloma and nasal polyps, they were detected in (62.9% and 74.3%), respectively where the results have revealed highly significant differences (P<0.01). Overexpression of p73 in nasopharyngeal, sinonasal benign and malignant tumor tissues in comparison with healthy control has been noticed. The significant detection of HCMV along with P73 genes expression in nasopharyngeal and sinonasal cancer patients could point for an sharing etiologic role for both of them in carcinogensis. Top Keywords NPC, SNC, pp65-HCMV, P73, CISH, IHC. Top |