Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 4
First page : ( 569) Last page : ( 572)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00351.7

Assessment of Serum Vitamin B9 and B12 in the Iraqi Pregnant Women

Kadhim Bushra Mohammad

Assistant teacher in Ministry of Education, General Education in Baghdad, Karkh/2

Online published on 27 November, 2019.

Abstract

Folate (vitamin B9) is an vital nutrient that is essential for DNA replication. Also, in the range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism as a substrate. Vitamin B12 is also known as cobalamin. It is present in number of forms including cyano-, methyl-, deoxyadenosyl-and hydroxy-cobalamin. This study included 50 pregnant women enrolled at Al-Karkh Materuity hospital in December 2019 to June 2019. Fasting blood (n=25) was collected by a single puncture form cases (either showed vitamin B9 or B12 deficiency) and healthy participants (n=25) after obtaining informed consent. The parameters like child birth weight, type of delivery and duration of pregnancy was recorded. The fasting blood was collected (2ml) in the plain vacutainers from the vein after getting oral consent from the participants. Serum vitamin B9 (folate) and vitamin B12 content were estimated by commercially available kits (Sigma, USA). The unpaired t-test was done to estimate the statistical significance using GraphPad Instat (3.0, Trial Version). Compared to the healthy control, women with low vitamin B9 levels showed significant (p≤0.0001) decrease in the fetus weight. Similarly, B12 deficient women showed decreases in child birth weight as compared to healthy control. Vitamin B9 was found to be 174.38213±85.17 pmol/l in the healthy control while it was 119.8785±25.81pmol/l in the B9 deficient participants. The vitamin B12 content was significantly lower (211.649±31.71pg/ml) in the B12 deficient group as compared to healthy control (401.472±58.94 pg/ml). From the present study, we can conclude that the vitamin B9 nad B12 are very essentical in the fetus growth and development. The supplementation should the start before planning the pregnanacy. The folate (Vitamin B9) and vitamin B12 are negatively associated with the pregnancy complications.

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Keywords

Vitamin B9, Vitamin B12, pregnancy outcome, carbon metabolism, child birth weight.

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