Role of Forkhead box O 3 (FoxO3) Protein in Iraqi Patients with Knee Osteoarthritis (KOA) Khalaf Mustafa Saleam1, Joda Abbas Toma2, Kwaeri Estabraq Abdulrasool3 1Al-Nahrain University, College of Medicine, Baghdad, Iraq 2Al-Mustansiriya University, College of Medicine, Baghdad, Iraq 3Al-Nahrain University, College of Medicine, Baghdad, Iraq Online published on 27 November, 2019. Abstract Objective To shown the role of Forkhead box O 3 (FoxO3) protein in development of primary Knee osteoarthritis (KOA) in Iraqi patients, this study done in Baghdad-Iraq at September 2018. Method The samples collection were take from KOA patients and controls in Rheumatology & Rehabilitation Consultation Unit in Al-Yarmouk Teaching Hospital/Iraq. Diagnosis of cases with KOA was according to American College of Rheumatology (ACR), and the FoxO3 protein measured in serum by ELISA technique. Results In this study demonstrad that the patients with KOA grade 1 have non significant decrease (3.54 1.33) in FoxO3 protein level but patients with KOA grade 4 have significant decrease (1.174 1.142) compare with controls (3.58 1.31) at Iraqi patients at old age. Also explain significant decrease when compare grade1 with 4 of KOA patients. Conclusion Conclude this study that FoxO3 protein level decrease with KOA development and support inhibit of autophayg and antioxident procces, this can lead to primary KOA progression. Top Keywords Forkhead box O 3 (FoxO3) protein, Knee osteoarthritis (KOA), autophagy. Top |