Evaluation of Serum Transaminases in Type 2 Diabetes Mellitus Rao K.V.N. Mallikarjuna1,*, Pusapati Surya Meenakshi2, Kumar N. Laxmana3 1Associate Professor, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh 2Student, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh 3Professor, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh *Corresponding author email id: kotamalli@gmail.com
Online published on 4 February, 2017. Abstract Background Liver is the central hub for metabolism. Liver dysfunction in diabetes mellitus is one of the major causes of morbidity and mortality. Periodical evaluation of transaminases helps in early diagnosis of liver dysfunction. Aim The aim of the present study is to measure aspartate transaminase (AST) and alanine transaminase (ALT) in known cases of type 2 diabetes mellitus (T2DM) and to compare the values with matched controls. Settings and Design Institutional cross-sectional observation study. Methods & Material Study was done in 100 known cases of T2DM and in 30 controls. Age, AST, ALT and fasting plasma glucose (FPG) were recorded, analysed and compared between two groups. Statistical Analysis Data was analysed using Microsoft Excel 2007 and SPSS trial version 16.0. Results Significant difference between FPG, AST, ALT and age were observed between two groups (P < 0.05). Conclusion The results from our study showed that there are elevated levels of ALT and ASTs among T2DM patients when compared with normal individuals. Top Keywords Diabetes mellitus, Aspartate transaminase (AST), Alanine transaminase (ALT), Age, Fasting plasma glucose (FPG), Nephropathy, Ischaemic heart disease. Top |