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Indian Journal of Mednodent and Allied Sciences
Year : 2018, Volume : 6, Issue : 2
First page : ( 59) Last page : ( 65)
Print ISSN : 2347-6192. Online ISSN : 2347-6206.
Article DOI : 10.5958/2347-6206.2018.00009.2

Role of haematological parameters in oral potentially malignant disorders and oral squamous cell carcinoma-A comparative study

Preethi P.1, Shyam N.D.V.N.2,*, Vaishali N.3, Poornima R.1, Shravani R.1, Priyanka M.1

1Post Graduates, Department of Oral Pathology, Government Dental College and Hospital, Afzal Gunj, Hyderabad, 500012, Telangana, India

2Professor and HOD, Department of Oral Pathology, Government Dental College and Hospital, Afzal Gunj, Hyderabad, 500012, Telangana, India

3Assistant Professor, Department of Oral Pathology, Government Dental College and Hospital, Afzal Gunj, Hyderabad, 500012, Telangana, India

*Corresponding author email id: ndvnshyam@gmail.com

Online published on 24 August, 2018.

Abstract

Context

Oral squamous cell carcinoma (OSCC) is one of the most common cancers in human population and has a multifactorial aetiology. It is often preceded by oral potentially Malignant Disorders (OPMDs). Studies have shown that OSCC and OPMDs cause significant variations in various haematological parameters.

Aim and objectives

To assess the role of haematological parameters like haemoglobin, erythrocyte sedimentation rate, red blood cell count, white blood cell count and differential leukocyte count in OPMDs and OSCC and also to compare these parameters among OPMDs, OSCC and controls.

Materials and methods

Study comprises 30 diagnosed cases each of OPMDs and OSCC and 10 normal healthy age and sex-related individuals. Blood sample was collected from the patients and was evaluated for various haematological parameters by Sahli's acid haematin method, Westergren method and Coulter Counter ZF-6.

Results

There was a statistically significant difference in haemoglobin, red blood cell count, erythrocyte sedimentation rate, differential leukocyte count between OSCC, OPMDs and controls.

Conclusion

In the present study, haematological parameters were significantly altered in OPMDs and OSCC, and these variations may be useful in the prediction of malignant transformation and prognosis.

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Keywords

Differential leukocyte count, WBC count, Erythrocyte sedimentation rate, Haemoglobin, Oral potentially malignant disorders, Oral squamous cell carcinoma.

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