Carbapenem-resistant Enterobacteriaceae: Prevalence and bacteriological profile in a tertiary teaching hospital from rural western India Pawar Satyajeet K1,*, Mohite S. T.2, Shinde R.V.3, Patil S.R.4, Karande G.S.5 1Associate Professor, Dept. of Microbiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 2Professor, Dept. of Microbiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 3Associate Professor, Dept. of Microbiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 4Professor, Dept. of Microbiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India 5Professor and Head, Dept. of Microbiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India *Corresponding Author: Email: drskpawar@gmail.com
Online published on 14 January, 2019. Abstract Introduction In last few years, Gram-negative bacilli are isolated capable of producing various classes of carbapenemases with ability of hydrolyzing the β-lactam antimicrobial. Carbapenem Resistant Enterobacteriaceae (CRE) have been reported worldwide. There is a serious threat to public health due to the emergence and rapid spread of CRE. Aims To find prevalence and bacterial profile of CRE in clinical isolates in indoor patients from a rural tertiary care centre. Materials and Methods The study was conducted in a tertiary care teaching hospital in Western India, June 2016 to April 2018. The clinical specimens received in microbiology laboratory were processed by the standard method. Bacteria were identified by VITEK 2 compact (Biomerieux) automation system, and antimicrobial susceptibility testing was done with the same system to detect minimum inhibitory concentrations for carbapenem group of antimicrobials. CLSI 2016 guidelines were used to detect CRE. Results Total 535 Enterobactericaeae clinical isolates were included in the study. Of these, 31.77% (n=170) were CRE. Specimens like urine, pus/wound swab and endotracheal tube secretion were the major contributors for CRE isolates.82% of CRE were Klebsiella pneumoniae (63%) and E.coli (19%). Conclusions A high prevalence of 31.77% carbapenem resistance was observed among Enterobacteriaceae isolates. Early detection, isolation and contact precaution of CRE patients will help to prevent rapid dissemination of CRE infection. Top Keywords Carbapenem Resistant Enterobacteriaceae, CRE, Carbapenemase, Klebsiella pneumoniae.. Top |