Comparative effect of fixed dose combination of Amlodipine + Bisoprolol versus Amlodipine and Bisoprolol alone on blood pressure in stage-2 essential hypertensive patients Shirure PA1,*, Tadvi NA2, Bajait CS3, Baig MS4, Gade PR5 1Dept of Pharmacology, GMC, Nanded, Maharashtra 2Dept. of Pharmacology, KIMS, Narketpally, Andhra Pradesh 3Dept of Pharmacology, GMC, Nagpur, Maharashtra 4Dept of Pharmacology, GMC, Aurangabad, Maharashtra 5Dept of Pharmacology, MIMSR Medical College, Latur, Maharashtra *Corresponding author Email: drprashantshirure@yahoo.com
Online published on 6 April, 2013. Abstract Background Employment of low dose combinations of two antihypertensives, with different mode of action has gained acceptance worldwide for the treatment of mild to moderate hypertension. However, most studies in hypertensive disease have focused on monotherapy. The combination therapy in the treatment of hypertension is largely extrapolated from these monotherapy studies. Objectives To study and compare the effect of amlodipine, bisoprolol and fixed dose combination of amlodipine + bisoprolol on blood pressure in stage-2 essential hypertensive patients. Method The present study was carried out in Department of Pharmacology in collaboration with Department of Medicine at Government Medical College and Hospital, Aurangabad. Results and Conclusion Amlodipine + bisoprolol in fixed dose combination have showed significant blood pressure control in patients of stage-2 essential hypertension and the antihypertensive effect was greater than individual monotherapy study groups. Top Keywords Amlodipine, Bisoprolol, Hypertension stage-2. Top |