Beneficial effect of low dose amlodipine vs nifedipine on serum cholesterol profile of rabbits receiving standard diet Bavane DS*, Rajesh CS, Moharir Gurudatta, Ambadasu Bharatha Department of Pharmacology, Shri. B. M. Patil Medical College & Research Centre, BLDE University, Bijapur-Karnataka *Corresponding author e-mail: ajaybawane02@gmail.com
Online published on 6 April, 2013. Abstract Objective To investigate the effect of low dose amlodipine v/s nifedipine on serum cholesterol profile of rabbits receiving standard diet. Methods Fourty Newzealand rabbits were selected for the study. Their cholesterol profile was estimated at the beginning of the study. Rabbits were grouped into 4 groups receiving standard diet (control group), standard diet + vehicle propylene glycol, standard diet + nifedipine dissolved in propylene glycol and standard diet + amlodipine dissolved in propylene glycol. Along with standard diet they were treated with respective drugs for ten weeks. At the end of ten weeks serum cholesterol profile was estimated. Results The cholesterol profile was estimated at the beginning and at the end of ten weeks. Total cholesterol in the amlodipine group decreased from 97±4.06 mg/dl to 90±4.2 mg/dl and HDL-Cholesterol increased from 32.01±4.40 mg/dl to 37±4.60 mg/dl after 10 week treatment but these changes were not significant. LDL cholesterol decreased significantly in rabbits with low dose of amlodipine from 55.42±3.32 mg/dl to 32.40±3.22 mg/dl and. In the nifedipine group there was a slight increase in total cholesterol from 102.49±5.16 mg/dl to 106±5.39 mg/dl, HDL cholesterol from 34.10±2.80 to 35.16±2.82 mg/dl and LDL cholesterol also increased from 56.20±2.20 mg/dl to 59.00±2.20 mg/dl after 10 week treatment. Conclusion The study shows amlodipine produces favorable alterations in serum cholesterol profile. Top Keywords Cholesterol profile, Standard diet, Amlodipine, Nifedipine. Top |