Lipid indices in typeii diabetes mellitus and their association with macro and micro vascular complications Siddiqui Imran Ahmed1,*, MD, B Laxmikanth2, MD, Mariya3, MD, Rao J Rama4, MD 1Specialist, Department of Biochemistry, ESIC Super Specialty Hospital, Hyderabad 2Asst Professor, Department of Biochemistry, Shri Sathya Sai Medical College & Research Institute, Chennai 3Asst Professor, Department of Anatomy, Shadan Institute of Medical Sciences, Hyderabad 4Professor & Head Department of Biochemistry, Osmania Medical College, Hyderabad *Corresponding author email: write2drimran@gmail.com
Online published on 6 April, 2013. Abstract Background Type II Diabetes Mellitus patients can develop complications over a prolonged period of time. The alterations in lipid indices can be associated with these complications. Aims To identify changes in lipid metabolism in type 2 DM in context with the glycemic status, its relative impact on the macro & micro vascular events, and the effects of insulin therapy on the lipid indices. Methods and Material 158 Type II diabetics were selected as cases and 30 subjects without any coincidental illness as controls were selected for the study. Total cholesterol, Triglyceride, HDL-C, Cholesterol/HDL-C ratio and Atherogenic Index (AI) were estimated and the data was statistically analyzed. Results Atherogenic index and CHOL/HDL-C levels were significantly higher in diabetics than in controls. Both the indices were also found to be lowered in patients on treatment with insulin. The AI in patients with complications was also significantly higher than those without complications; however CHOL/HDL-C was not significantly different. Thus using the best cutoff values AI can be used as a better indicator for complications than using the ratio of CHOL/HDL-C. Conclusion AI can be used to indicate the presence of increased cardiovascular risk in patients with type II DM, and as a guide for the aggressive therapeutic approach. Top Keywords Type II DM, Lipid indices, Atherogenic index, Micro and Macro vascular complications. Top |