Maternal and neonatal outcome in pre-eclamptic mothers with elevated liver enzymes: A prospective analytical study Mahajan Puneeta1, Gupta Vinita2, Chaudhary Aarushi3,*, Mehta Shinky4 1Medical Director, Dept. of Obstetrics and Gynaecology, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, New Delhi, India 2OBG Specialist, Dept. of Obstetrics and Gynaecology, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, New Delhi, India 3Secondary DNB Resident, Dept. of Obstetrics and Gynaecology, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, New Delhi, India 4Senior Resident, Dept. of Biochemistry, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, New Delhi, India *Corresponding Author: Email: prof.aarushi@gmail.com
Online published on 24 September, 2018. Abstract Introduction Hypertensive disorders during pregnancy may cause damage to liver which may manifest biochemically as a deranged liver function test and subsequent maternal morbidity and mortality any elevation in liver enzymes in a pre-eclamptic patient is significant and influences fetomaternal outcome this study evaluates the liver enzymes as a diagnostic and therapeutic tool in the management of preeclampsia and establishes a correlation between severity of liver function test derangement and severity of fetomaternal complications and use it as a predictive tool of severity of preeclampsia and for termination of pregnancy. Aim was to evaluate maternal and neonatal outcome in pre-eclamptic mothers with and without transaminitis. Primary objective of the study was to compare the maternal and neonatal outcome in pregnant women with preeclampsia in singleton pregnancies with gestational age >24 weeks with and without transaminitis. Secondary objective was to correlate the severity of liver enzyme derangement in preeclamptic mothers with adverse maternal and/or fetal outcome and use it as a predictive tool of severity of preeclampsia and for termination of pregnancy Materials and Methods This prospective cohort study was conducted on 281 patients after approval by the institute ethics committee informed consents were taken from patients inclusion and exclusion criteria were met all enrolled patients were classified into mild, moderate and severe hypertension and managed as per standard guidelines. Specific investigations were performed if during any visit ast >25 iu/l and/or alt >32iu/l and/or alp > 418 iu/l, patients were called again after a week and blood pressure and fetomaternal well-being was assessed termination of pregnancy was done as per standard guideline statistical analysis done and hypothesis established. Results From the present study it can be derived that at ast >66 iu/l and alt > 64 iu/l poor maternal outcome is expected with ast >60 iu/l and alt>64 iu/l adverse fetal complications are likely to occur. Conclusion From the present study it can be concluded that severity of liver function test derangement is directly related to severity of preeclampsia which in turn is related to severity of fetomaternal complications. Top Keywords Elevated liver enzymes, Preeclampsia, Maternal, Neonatal outcome. Top |