Correlation of HbA1c Levels with Monocyte-lymphocyte and Platelet-lymphocyte Ratios in Type 2 Diabetics of Bengaluru City Suguna S1, Kusumadevi M.S.2,* 1Associate Professor, Department of Physiology, Bangalore Medical College and Research Institute, Fort, K R road, Bengaluru-560002, Karnataka, India 2Professor, Department of Physiology, Bangalore Medical College and Research Institute, Fort, K R road, Bengaluru-560002, Karnataka, India *Corresponding Author: M.S. Kusumadevi, Professor, Department of Physiology, Bangalore Medical College and Research Institute, Fort, K R road, Bengaluru-560002, Karnataka, India
Online published on 21 November, 2019. Abstract Background Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. These complications in type 2 DM has an inflammatory pathology. Many inflammatory markers have been found to be related to these complications, such as interleukin1 (IL1), IL6, IL8, transforming growth factor beta 1 (TGF-β1) and tumour necrosis factor alpha (TNF α). However, their measurement is not used routinely as it is not easy to do it, in this respect. The white blood cell (WBC) count and its subtypes are classic indicators of inflammation and their measurement is done routinely and also their estimation is cost effective. To correlate HbA1c levels with monocyte-lymphocyte and platelet-lymphocyte ratios in type 2 diabetics of Bengaluru city. Materials and Method A total of 50 type 2 diabetics without complications were included in the study with a mean age of 55.78 (SD: 13.77) years of both gender previously diagnosed regardless of their sociodemographic characteristics and were invited for the assessment of complete blood count (CBC) and HbA1c levels in Infilife healthcare private limited of Bengaluru city. The platelet-lymphocyte ratio and monocyte-lymphocyte ratio were calculated as the ratios of the platelets and monocytes to lymphocytes, respectively. All counts were determined from the same automated blood sample measurement. Results Mean (SD) P/L ratio and M/L ratio were 0.14 (0.36) & 7.37 (3.43) respectively. There was no significant correlation (at p=0.05) between HbA1c levels and P/L ratio[r= (−0.46)]) and L/M ratio[r=0.05]. Conclusion In the present study, there was no statistically significant correlation between HbA1c levels and P/L ratio[r= (−0.46)]) and L/M ratio[r=0.05] in patients with type 2 diabetes mellitus of Bengaluru city. Top Keywords HbA1c, monocyte-lymphocyte and platelet-lymphocyte ratios, type 2 diabetes mellitus. Top |