Status of Lipid Peroxidation and Iron Levels in Bronchial Asthma Ramadevi P.1, Kumar A.V. Siva2,*, Maruthy K.N.3, Kumar Ch. Kiran4, Sasikala P.3 1Assistant Professor, Dept. of Physiology, ACSR Medical College 2Faculty/Ph. D. Research Scholar, Department of Physiology, Narayana Medical College 3Professor, Department of Physiology, Narayana Medical College 4Associate Professor, Department of Physiology, Narayana Medical College, Nellore *Corresponding Author: Mr. A.V. Siva Kumar, Faculty & Ph. D. Scholar, Department Of Physiology, Narayana Medical College, Nellore-524003 Contact: +918341644980, 8555844682, e-mail: reddy.sivakumar5@gmail.com
Online published on 21 November, 2019. Abstract Introduction The Oxidative stress, specifically lipid peroxidation, is believed to contribute to the pathophysiology of asthma. Low antioxidant levels and oxidative stress due to airway inflammation may be determinant of asthma severity. Level of plasma malondialdehyde (MDA) was used as index of lipid peroxidation. Even elevated iron levels also contribute for production of ROC and free radicals which causes inflammation in bronchial asthma. So the present study was aimed to reveal the relationship between lipid peroxidation and bronchial asthma. Method The FEV1% was measured to categorize the asthmatic patients and controls. Later MDA and serum iron levels were measured in thirty asthma cases and 30 healthy volunteers aged between 18–45 years. All the procedures were performed in the morning after their light breakfast in a less noise and illuminated room. Results The results showed serum MDA and iron levels significantly increased in bronchial asthmatic patients were suggestive of lipid peroxidation and oxidative stress in asthmatic patients compared to controls. Conclusion Therefore, Oxidative stress and lipid peroxidation are the key factors to produce ROC and free radicals which aggravates bronchial asthma. Top Keywords Oxidative stress, Body Mass Index, Bronchial asthma, Lipid peroxidation. Top |