Comparison of Serum Calcium Levels in Euthyroid, Subclinical and Overt Hypothyroid Women in the Tribal Belt of West Midnapore, West Bengal Vashisth Sanjay1, Chhetri Alpana2,* 1Associate Professor, Department of Physiology, Midnapore Medical College, Paschim Medinipur, West Bengal 2Assistant Professor, Department of O&G, CSS College of Obstetrics, Gynaecology and Child Health, 37 S. P Mukherjee Road, Kolkata, West Bengal *Corresponding Author: Dr Alpana Chhetri Flat E 209, Sunrise Estate, 14/C Radhanath Chowdhury Road, Kolkata-700015. Phone: +91 98309 83496, +91 9830519741
Online published on 21 February, 2019. Abstract Background Thyroid disease has wide spread manifestation on bone metabolism and serum calcium levels. There has been wide attention on thyrotoxicosis and calcium metabolism but less study has been done on subclinical and overt hypothyroidism and its effect on calcium level. Our study was done to assess calcium levels and compare it between euthyroid, subclinical and overt hypothyroidism. Study Design Prospective Cross-sectional study Materials and Method With prior consent, 300 women were selected, between 20 to 60 years of age, from the tribal belt of Midnapore districts who attended the medicine OPD of Midnapore Medical College over the period of six months. The serum calcium was measured by ion selective electrode method and was analyzed by chemical analyzer. Free T4 were estimated by equilibrium dialysis and TSH was estimated by immunoassay method. Results It was found that 48 women were found to have hypothyroidism, out of which 18 women were found to have overt hypothyroidism and 30 had subclinical hypothyroidism. FT4 levels showed positive correlation with serum calcium levels in Euthyroid, Subclinical and Overt Hypothyroid, but the correlation was significant only with free T4 levels in overt hypothyroidism. The comparison of values of freeT4, TSH and Calcium levels in subclinical and overt hypothyroid were highly significant. Conclusion This study shows that there exists a positive relationship between free T4 and serum calcium levels in overt hypothyroidism. Top Keywords Serum Calcium, subclinical and overt hypothyroidism, tribal belt, women, Midnapore. Top |