Effect of Vitamin C Supplementation on Insulin Resistance, β-cell Function and Insulin Sensitivity in Obese and Non Obese Individuals Ghanwat Ganesh H.1, Sontakke Ajit V.2 1Tutor, Department of Biochemistry, Krishna Institute of Medical Sciences, Karad, Maharashtra (India) 2Professor and HOD; Department of Biochemistry, Krishna Institute of Medical Sciences, Karad, Maharashtra (India) Online published on 21 February, 2019. Abstract Background Insulin resistance (IR) is common pathological feature of most of the metabolic disorders including obesity. Vitamin C intake seems useful to counteract obesity and associated complications. Aim and Objectives Present research was aimed to study the effect of vitamin C intake on fasting blood glucose, insulin, Homeostatic Model Assessment (HOMA) of Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) and Quantitative Insulin Sensitivity Check Index (QUICKI) in obese and non obese subjects. Material and Method Total 80 subjects; (42 centrally obese and 38 non obese) were involved in the present study, they received 500 mg vitamin C thrice a day for 3 months. Results Significant decrease in fasting blood glucose, serum insulin, HOMA-IR and significant increase in QUICKI in all obese subjects and non obese males, except serum insulin in non obese males. No significant change in any of the parameters in non obese females and in HOMA-β, in all subjects was observed after vitamin C intake. Conclusion This study indicates three months of 1500 mg/day of vitamin C intake is helpful to revert obesity and otherwise induced insulin resistance and increase insulin sensitivity index. Top Keywords Obesity, HOMA-IR, HOMA-β, QUICKI, Waist circumference. Top |