The Effectiveness of Extract Klika Streculiapopulifolia Cream on the Collagen of Albino Mice against Ultraviolet B Radiation Khairi Nur1,*, As'ad Suryani2, Djawad Khairuddin3, Alam Gemini4 1Department of Pharmaceutics, School of Farmasi, Makassar, Indonesia 2Department of Nutrition Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 3Department of Dermato-venereology, Faculty of Medicine 4Departmenta of Pharmacognosy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia *Corresponding Author: Nur Khairi Department of Pharmaceutics, School of Farmasi, Makassar, Indonesia Email: nurkhairijalil@gmail.com
Online published on 21 February, 2019. Abstract Sterculiapopulifoliaextract contains flavonoid and polyphenol compounds which are the most potential components in reducing ROS (Radical Oxidative Superoxide) to prevent skin damaged caused by UV-B radiation. This study aims to assess the effectiveness of cream extract klikaSterculiapopulifolia to the thickness and density of collagen in albino mice skin after being exposed to UVB. This study was a laboratory experimental study using randomized post-test design. Albino mice were divided into 3 groups; group 1 was treated with klikaSterculiapopulifolia extract cream and exposed to UVB radiation, group 2 was treated with base cream/placebo and exposed to UVB radiation, and group 3 was controlled group (not given anything and not exposed to UVB radiation). the treatment group was exposed to UV-B radiation at a dose of 500 mJ/cm2 for 4 weeks. After that skin biopsy was performed to examine collagen.klikaSterculiapopulifolia extract cream group showed collagen density higner than base cream group. No significant differences between klikaSterculiapopulifolia extract cream and contolled group. klikaSterculiapopulifolia extract cream can increase the thickness and density of collagen in mice skin exposed to UVB. Top Keywords Klika Sterculiapopulifolia extract cream, collagen, ultraviolet-B. Top |