The Protective Role of Hydatid Cyst against Colorectal Cancers Mohammed Asmaa Murtadha1, Hamza Dhamiaa Makki2, Mohammed Sabah Neamah3 1M. Sc., Department of Medical Microbiology and Immunology, College of Medicine, University of Kerbala 2Assistant Professor, Department of Medical Microbiology and Immunology, College of Medicine, University of Kerbala 3M.B.CH.B F.I.B.M, Immunologist, AL-Sadar Medical City of Najaf, Iraq Online published on 21 February, 2019. Abstract Background many research groups studied the relationship between cancers and parasitic infections as some parasite considereded to be the cause of malignancies, while others have antitumor activities against cancers. So the correlation between both is still a debate issue. Aim This study is designed to show if the patients with the hydatid cyst infection have protection against colorectal cancer, in other words, if hydatid cyst gives a percent of protection against colorectal cancer in future. Method A case/control study conducted from September 2017 to June 2018. Three group study have been involved who they attended different hospital in the al-Najaf city, the first one cystic hydatidosis patients (46 patients attended to different hospitals in Najaf city), the second group colorectal cancer patients(46 patients attended the Middle Euphrates Oncology center), the three group apparently healthy control (48 participants). Four types of tests were done, Chemiluminescence immunoassay (CLIA) for CEA measurement, CLIA for CA19.9 measurement, ELISA assay for human Echinococcus granulosus IgM (Eg IgM) and ELISA assay for human (Eg IgG), chi-square, p-value, and odds ratio were used for statistical analysis. Results Colorectal cancer show a high level of tumor marker CA19.9 (45.7%) and CEA (52.2%) compare to hydatid cyst and control was 0% for both, and the odd ratio, it was 1.7 for seropositive IgG and 2.09 for seropositive IgM. Conclusion This data suggest that hydatid cyst can occur in the patient with colorectal cancer. Top Keywords Colorectal cancer, hydatid cyst, the protective role. Top |