Pulp Response Capped by Brain Derived Neurotrophic Factor (BDNF) Al-Hijazi Athraa Y.1,*, Ali Mukhaled L2, Hasan Dhuha M1, Al-shamma Abdulla MW3 1Al-Mustaqbal University College Dentistry Department Babel, Iraq 2College of Dentistry, Babylon University, Babel, Iraq 3College of Dentistry, University of Baghdad, Iraq *Corresponding Author: Athraa al-hijazi Al-Mustaqbal University College Dentistry Department, Babel, Iraq Email: athraayms@yahoo.com
Online published on 21 February, 2019. Abstract Background Four n-eurotrophins (NTFs) are a family of structurally related proteins with specific effects on the developing nervous system and non-neuronal differentiating cells. The brain-derived neurotrophic factor (BDNF) has role in differentiation of pulp cells into mineralizing cells, and that was identified as survival factor, development and function of dental tissues. Aim of the study The study was designed to illustrate pulp response capped by brain-derived neurotrophic factor after mechanical trauma. Materials and Method Brain derived neurotrophic factor was used as pulp capped material for maxillary anterior teeth of (12)rat following the mechanical traumatized proceduce. Pulp reaction was studied histologically from the first cutting procedure, followed by interval periods (48, 72, 168 hours), Six teeth for each period. Results Illustrated an enhancement of pulp healing represented by newly apposition of reparative dentine with presences of active angiogenesis followed by globular minerlization that coincides with proceeding interval time. Conclusion The study suggest that BDNF contributes in pulp healing and can be addressed to a more conservative treatment approach. Top Keywords Brain derived neurotrophic factor, tooth structure, dental cell, dental pulp, pulp capping. Top |