Hepatoprotectie Effect of Bromelain against Gentamicin-Induced Hepatic Damage in Rats Murad Hawraa M.1, Faris Jawad Kadhim2, Naji Hawraa H.2, al-bawi Firas Hussein Kadhim1, Ibrahim Nadya Jamal2 1Department of Pathology, Al-Qasim Green Uniersity, Iraq 2Department of Physiology and Pharmacology, Al-Qasim Green Uniersity, Iraq Online published on 21 February, 2019. Abstract This study was conductedto assess the protectie effect of bromelain(BROM), on any hepatotoxicity inducedby gentamicin (GNT) in rats. GNT is used for the treatment of Gram-negatie bacterial infections. Howeer, GNT in administration is limited because of hepatotoxicity. Twenty four rats were diided into four groups: control, (1 ml/kg Saline orally) and GNT (100 mg/kg), intraperitoneally(i/p)), and GNT (i/p) plus BROM (20 mg//kg) orally, and GNT (i/p)) plus BROM (40 mg//kg) orally for (10) consecutie days. All the rats were killed on the (11) day of the experiment, and then the blood, and liers samples were taken GNT induced hepatotoxicity was proed by a significant (p < 0.01) reduction in the body weight, and a significant (p < 0.01) increased serum glutamic oxaloacetic transaminase (GOT), serum glutamic-pyruic transaminase (GPT), Total protein(TP), Malonaldehyde enzyme (MAD) and histopathological changes. Protectiehepatic toxicity effect and oxidatie damage caused by GNT significantly (p < 0.01) increasing in body weight and significantl (p < 0.01) decreasing GOT, GPT, TP, MAD and improing tissue morphology in BROM (20 mg//kg) while, BROM (40 mg//kg) has little effect. These results confirm that BROM (20 mg//kg) antioxidant effects can protect GNT-induced hepatotoxicity in rats. Top Keywords Bromelain, Gentamicing, Anti-oxidantn, Ratsf. Top |