The Incidence of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Dr. Saiful Anwar General Hospital Malang, Indonesia from 2012–2017 Ratnaningrum Safrina Dewi1,2,*, Lyrawati Diana3, Murlistyarini Sinta4, Nurdiana5, Nazwar Tommy Alfandy6 1Department of Anatomy Histology, Faculty of Medicine, Brawijaya University, Indonesia 2Doctoral Program in Medical Science, Faculty of Medicine, Brawijaya University, Indonesia 3Department of Pharmacy, Faculty of Medicine, Brawijaya University, Indonesia 4Department of Dermatology & Venereology, Dr. Saiful Anwar General Hospital, Indonesia 5Department of Pharmacology, Faculty of Medicine, Brawijaya University, Indonesia 6Department of Neurosurgery, Dr. Saiful Anwar General Hospital, Indonesia *Corresponding Author: Safrina Dewi Ratnaningrum S. Si., MSi. Med., Department of Anatomy Histology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia Phone: +62-341-551611 (ext.151) Email: safrina.fk@ub.ac.id
Online published on 21 February, 2019. Abstract Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but unpredictable severe hypersensitive reactions with high significant mortality and potentially life-threatening. Indonesia has a large population but study of SJS/TEN in Indonesia is still limited. The purpose of our study was to describe data the patients profile, incidence, mortality, and related diseases based on ICD-10 nomenclature system of all patients with SJS and TEN, retrospectively. Medical records of hospitalized patients with SJS (L51.1), TEN (L51.2) and SJS/TEN overlap (L51.3) from January 1, 2012 to December 31, 2017 in dr. Saiful Anwar General Hospital Malang, Indonesia were reviewed. The study has obtained 75 SJS/TEN (63 SJS; 12 TEN) patients data from 2012–2017 with incidence rate was 12.5 cases per years. No SJS/TEN overlap was observed. This study demonstrates that SJS/TEN were more frequent in middle adulthood than other age groups. In SJS, female were more frequent than male. In contrast, male more susceptible to TEN than female. The mortality rate was 9.5% in SJS and 16.7% in TEN or 10.67% in total. Based on ICD-10 classification, eye and adnexa disorder, infection, and endocrine, nutritional, metabolic abnormality were the most frequent complication in SJS and TEN. Top Keywords Incidence, Stevens Johnson syndrome, toxic epidermal necrolysis, ICD-10. Top |