Comparative Study on the Protective Effect of L-Carnitine in Combination with Beta-Carotene against Overdose Acetaminophen Induced Hepatotoxicity and Nephrotoxicity in Adults Male Rats Al-Rekabi Bassim Khamess Kuoti1,*, Al-Shwilly Hatim A J1 1Department of Animal Production, College of Agriculture, University of Sumer, Thi-Qar, Iraq *Corresponding author: Bassim Khamess Kuoti Al-Rekabi. Department of Animal Production, College of Agriculture, University of Sumer, Thi-Qar, Iraq; E-mail: kh_bassim@yahoo.com.
Online published on 21 February, 2019. Abstract This study was designed to evaluate the protective effect of exogenous L-carnitine alone and their combination with beta-carotene against acetaminophen (paracetamol) induced hepatic and renal damage in adult male rats. Thirty male rats 175–200 gram, 12–13 weeks old were randomly divided into five equal groups, 6 animals per each as follows: Control group (negative control): received distilled water orally 1ml/kg/day. First treated group (positive control, T1): received paracetamol 500 mg/kg/day I.P for 14 days. Second treated group (T2): received paracetamol 500 mg/kg/day I.P for 14 days and after 1hours later received L-carnitine orally 500 mg/kg/day. Third treated group (T3): received paracetamol 500 mg/kg/day I.P for 14 days and after 1 hours later received beta-carotene dissolved in olive oil (50%, 1: 1v/v) orally 20 mg/kg/day. Fourth treated group (T4): received paracetamol 500 mg/kg/day I.P for 14 days and after 1 hours later received half a dose above of L-carnitine 250 mg/kg/day + beta-carotene 10 mg/kg/day orally. The obtained results illustrated that male rats treated with PCM significantly increase AST, ALT, ALP, MDA, urea, and creatinine. Top Keywords L-Carnitine, Beta-Carotene, Paracetamol, Hepatotoxicity, Nephrotoxicity. Top |