Vascular Endothelial Growth Factor/Vascular Permeability Factor and VEGF Gene Polymorphisms is Detectable Rheumatoid Arthritis Patients Salih Ishraq Abdul Ameer1,*, Omran Rabab2 1Department of Biology, Science For Women, University of Babylon, Iraq 2Department of Biology, Science, University of Babylon, Iraq *Corresponding author: Ishraq Abdul Ameer Salih. Department of Biology, Science For Women, University of Babylon, Iraq
Online published on 21 February, 2019. Abstract VEGF is a crucial mediator of angiogenesis. It has been implicated in neovascularization associated with cancer metastasis, as well as arthritis. Hypoxia present in the inflamed joints, as well as hypoxia-inducible factors mediate VEGF production that leads to endothelial cell prolifertaion and angiogenesis. Serum VEGF levels have been associated with the clinical activity of rheumatoid arthritis. VEGF targeting using anti-VEGF and anti-VEGF receptor antibodies, small molecule inhibitors of VEGF signalling has been utilized in oncology and, very recently, in arthritis therapy. A total of 70 unrelated IRAQ patients with RA and 40 healthy Iraqi volunteers with no family histories of any autoimmune diseases were recruited. The promoter VEGF gene polymorphisms were genotyped gene polymorphism implemented used RFLP technique. Serum VEGF levels in RA patients and controls were measured by ELISA. The results show The genotype distributions and allele frequencies of VEGF gene polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for VEGF gene. The frequencies of the A allele on the VEGF gene were significantly increased in RA patients. Top Keywords VEGF gene, VEGF protein, RFLP. Rheumatoid arthritis. Top |