Synthesis and Biological Activity of New Fused Heterocyclic Derived from 4-oxo-2-phenylquinazoline-3(4H)-carboxamide Kadham Sahar Abdullah* Department of Chemistry, College of Sciences, University of Mustansiriyah>, Iraq *Corresponding author: Sahar Abdullah Kadham. Department of Chemistry, College of Sciences, University of AL-Mustansiriyah, Iraq; E-mail: sahar1977@oumustansiriyah.edu.iq
Online published on 21 February, 2019. Abstract New 4-oxo-2-phenylquinazoline Derivatives like, pyrazole, pyrimidine and 1, 3-thiazoline moieties are reported. compound 1 was synthesized by the reaction of benzoyl chloride with anthranlic acid, compound 2 was converted into triazole, oxotriazino and thiotriazino. Compounds contains thiazole and Oxazole moieties 9, 10 and 11were synthesized by the reaction of chloro acetyl chloride with compound 3 and then with hydrazine, thiourea and thiosemicarbazide respectively. All structural of compounds have been confirmed by FTIR, 1HNMR and tested for invitro antibacterial activity against Escherichia coli, Staphylococcus aurous and Proteus mirabbilisby. Top Keywords Quinazoline, triazole, oxotriazino, thiotriazino, thiazole Oxazole. Top |