Chemo Preventive Efficacy of Aspirin in Colorectal Cancer: A Narrative Review Approach Abujamal Mohammed1,*, Abdalla Mariam2, Almodaimegh Hind3, Vasudevan Senthilvel4 1Lecturer, Pharmacy Practice Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs 2Lecturer, Pharmacy Practice Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs 3Associate Dean, College of Pharmacy, Female Branch King Saud Bin Abdulaziz University for Health Sciences, Cardiology Clinical Pharmacy Specialist, Program Director, Pharmacy Practice Residency, Cardiology King Abdulaziz Medical City 4Assistant Professor of Statistics, Department of Pharmacy Practice, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs, PO BOX 3163, Riyadh, 11481, Saudi Arabia *Corresponding Author: Mohammed Abujamal, MSc, BCPS, MBA, Lecturer, Pharmacy Practice Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs e-mail: ahmedmo@ksau-hs.edu.sa, Cell No: +966 540416667
Online published on 23 December, 2019. Abstract Objectives Our review is focused on aspirin efficacy as a chemo-preventive agent in colorectal cancer (CRC). Method We have searched related articles in the following data base through Pub Med, Science Direct, Cochrane Library, Scopus and Google Scholar, restricted to the studies from the year 2000 to 2015. This review focuses on the therapeutic efficacy of aspirin in CRC chemo-prevention. We provide an overview of the association of aspirin treatment with reduction of CRC incidence, recurrence, and CRC-related mortality. Results Regular use of aspirin was associated with significant reduction in the incidence and recurrence of colorectal cancer (p = 0.004), lower number of adenomas (p = 0.003), prolonged time of the first adenoma detection (p = 0.02) and lower risk of mortality (p > 0.001). Conclusion Regular use of aspirin effectively reduces the incidence of colorectal cancer, its recurrence rate, and its specific mortality. Top Keywords Chemo-Preventive, Aspirin, Recurrence, Efficacy, Colorectal Cancer. Top |