The Influence of Ginger (Zingiber Officinale Roscoe) to Protect Cholinesterase Enzyme Activities of Mice that Exposed to Pesticide Rachmaniyah1,*, Rusmiati1, Soenarko Bambang1 1Lecturer, Department of Environmental Health, Health Polytechnic of Surabaya, Indonesia *Corresponding Author: Rachmaniyah, Campus of Health Polytechnic of Surabaya, Pucang Jajar Tengah Street 56, Surabaya, Indonesia, e-mail: rachmaniyah.keslingsby@gmail.com
Online published on 23 December, 2019. Abstract Pesticide is a bioactive chemical inggredients that contain toxic material to kill pest organisms. Pesticides that is widely used in Indonesia were organophosphate and carbamate. These pesticides was known as inhibitor for the cholinesterase enzyme. The decreasing activity of cholinesterase enzyme can be solved by eat some food which contain antioxidant especially phytochemicals acid (vitamin C) and some others phytochemicals. To increase cholinesterase enzym level in farmers which exposed with pesticide we need to find a natural inggredients that is cheap, easy to find, easy to be processed, and untoxic. Ginger (Zingiber officinale Roscoe) was a plant that have lots of active inggredients and untoxic. The aim of this study was to analyse the influence of ginger extract as antioxidant to the cholinesterase enzym activity of mice that exposed to pesticide. This study was quasi experimental study using post test only control group design. Samples were Swiss Webster male white mice with 20–25 mg of weight, age 3–4 months, healty, and have a normal feces. There were 7 mice in every groups, all samples were 28 mice. Ginger (Zingiber officinale Roscoe) extract (0.001 mg/liter and 0.005 mg/liter) was given using feeding tube to every mice that have been exposed by 0.006 mg/liter of pesticide everyday. The results of cholinesterase enzyme test in mice which exposed by pesticide in control groups were 84%. Treatment groups with 0.005 mgr/liter of pesticide exposing, the cholinesterase enzyme level were 26%, treatment groups with 0.005 mg/liter of pesticide exposing and 0, 001 mg/liter, their cholinesterase enzyme were 77%. The K3 groups with 0.005 mg/liter of pesticides and 0.005 mg/liter ginger extract have the average level of cholinesterase enzym were 57%. We can conclude that ginger (Zingiber officinale Roscoe) extract can influence the cholinesterase enzym due to pesticide expose. Top Keywords Pesticides, cholinesterase, ginger (Zingiber officinale Roscoe). Top |