The Effectiveness of Treatment of Giant Gastric and Duodenal Ulcers with Endonasal Electrophoresis Dalargin (Tyrosyl-D-Alanyl-Glycyl-Phenylalanyl-Leucyl-Arginine Diacetate) Kaliberdenko V.B.1,*, Mametova L.2, Shanmugaraj K.3, Shterenshis M.V.4, Mametov K.5, Keerthanaa B.6, Shadchneva N.A.7 1Associate Professor, Department of Internal medicine No.2, V.I. Vernadsky Crimean Federal University, Simferopol, Russia 2Bureau Chief, Doctor for Medico-social Expertise, Federal State Institution “The Main Bureau of Medical and Social Expertise in the Republic of Crimea”, Simferopol, Russia 3Department of Internal Medicine No.2, V.I. Vernadsky Crimean Federal University, Simferopol, Russia 4Head of Science Research Department, Alexander Muss High School in Israel, Rishon LeZion Area, Israel 5Emergency Doctor, State Budgetary Institution of the Republic of Crimea “Crimean Republican Center for Disaster Medicine and Emergency Medical Aid”, Simferopol, Russia 6Department of Internal Medicine No.2, V.I. Vernadsky Crimean Federal University, Simferopol, Russia 7Associate Professor, Department of Internal Medicine No.2, V.I. Vernadsky Crimean Federal University, Simferopol, Russia *Corresponding Author: Vitalii B. Kaliberdenko, MD, PhD, Associate Professor. Simferopol, Russia Phone: +7(978)1222851, e-mail: vit_boris@mail.ru
Online published on 23 December, 2019. Abstract Peptic ulcer disease (PUD) results from an imbalance between stomach acid-pepsin and mucosal defense barriers. It affects 4 million people worldwide annually. The incidence of PUD has been estimated at around 1.5% to 3%. Purpose of our research is to study the effect of dalargin on the course of giant gastric ulcer (GU) and duodenal ulcer (DU). Materials and Method-The study and treatment was carried out in 80 people suffering from PU, with the presence of an ulcer defect ranging in size from 2 to 7 cm in diameter. Group 1–41 people received the drug from the group of proton pump inhibitors (PPIs)-omeprazole 20 mg 2 times per day + amoxicillin 500 mg 4 times per day + metronidazole 500 mg 3 times per day-7 days, i.e. standard triple therapy. Group II, 39 people received along with standard therapy, dalargin-endonasal electrophoresis No. 12 according to the standard technique. Results-Patients with PU in both groups, who received standard therapy and standard therapy + endonasal electrophoresis of dalargin, already for 2–3 days from the moment of the start of treatment, showed significant improvement. Conclusion-It is advisable to combine standard therapy in the treatment of giant ulcers with the use of reparants, in particular, with dalargin endonasal electrophoresis Top Keywords Peptic ulcer diseases, Giant ulcer, Gastric ulcer, duodenal ulcer, Dalargin, Gastroenterology. Top |