Determination the Role of Interleukin 31 (IL-31) Levels in Three Real Allergic Diseases (Asthma, Rhinitis, Urticaria) Hashim Ali F.1, Alubadi Alia E.M.2, Brakhas Suad A.1, Al-ani Intesar Y.3 1Department of Immunology, Allergy Specialist Center, Baghdad, Iraq 2Department of Biology, College of Science, University of Al-mustansiriyah, Baghdad, Iraq 3Renal Transplant Center, Medical City Hospital, Baghdad, Iraq Online published on 23 December, 2019. Abstract Interleukin-31 is a proinflammatory cytokine, has multiple physiological functions, including regulation of immune response, blood formation (hematopoiesis), and causing many diseases including dermatitis and airway hypersensitivity. The relationship between IL-31 and three types of allergic diseases (asthma, rhinitis, urticaria) are not quite described in the research, consequently, this study was done to demonstrate the levels of IL-31 in Baghdad population/Iraq. This study compared IL-31 levels in these three types who were positive for total and specific IgE in patients and compared with healthy controls were negative for total and specific IgE. A total of 148 allergic patients included in the present study with different allergic diseases (asthma, rhinitis, and urticaria) who diagnosed by the physician through clinical profiles and by lab investigation through total IgE and specific IgE, with the control group which was excluded the subjects who have a high level of the total IgE. The patients were recruited from Allergic Specialized Center\Baghdad-Resafa, Iraq. The level of interleukin 31 was measured in sera of 52 asthmatic patients, 48 rhinitis patients, 48 urticaria patients, and 28 control. The level of total IgE increases significantly in patients with allergy compared with control, and the levels of IL-31 in patients’ sera were significant increases in comparative with control; the present study provides new knowledge about the role of IL-31 into the underlying pathogenesis of allergic diseases. Top Keywords Asthma, rhinitis, urticaria, interleukin-31, total IgE. Top |