Functional Features of Platelets in Rats Fed a Standard Diet with Low Antioxidant Content During Ontogenesis Makurina Olga Nikolaevna1, Mal Galina Sergeevna2, Zavalishina Svetlana Yuryevna3,*, Medvedev Ilya Nikolaevich3 1Department of Biochemistry, Biotechnology and Bioengineering, Samara University, St. Academic Pavlov, 1, Samara, Russia, 443011 2Department of Pharmacology, Kursk State Medical University, St. K. Marx, 3, Kursk, Russia, 305000 3Laboratory of digestion and interstitial metabolism, All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals Institute of Village, Borovsk, Russia *Corresponding Author: Zavalishina Svetlana Yuryevna, Laboratory of digestion and interstitial metabolism, All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals, Institute of village, Borovsk, Russia, 249013, e-mail: svetlanazsyu@mail.ru, Tel +79102732263
Online published on 23 December, 2019. Abstract The Aim To evaluate the developmental dynamics of the hemostatic properties of platelets in rats with a low amount of antioxidants in their diet. The study took 116 healthy male Wistar rats, which during their lives contained on a standard diet, not rich in antioxidants, under normal vivarium conditions, including 23 rats of 3 months of age, 22 rats aged 6 months, 24 rats aged 12 months, 22 rats 18 months of age and 25 animals at the age of 24 months. In rats, their general state and parameters of biochemical and hematological blood parameters were determined. The results were processed by student's criterion. In the rats examined, the biochemical parameters of platelets and their activity remained stable between 3 and 6 months of life. The intensity of lipid peroxidation in the platelets of the observed rats remained normal until 6 months of age, and subsequently increased. In the blood plates of animals over the age of 6 months, the processes of self-assembly of the actin-myosin complex intensified and the content of platelets increased and the secretion of adenosine phosphates from them increased. Platelet activity in rats that are on the course of ontogenesis on the diet of not rich with antioxidants, grew older than 6 months and increased until the end of the observation-24 months. Top Keywords Ontogenesis, rats, platelets, aggregation, hemostasis, intravascular platelet activity. Top |