Analysis of Plasma F2-Isoprostane Level After Administration of Vitamin C in Patients with Chronic Tonsillitis Rahardjo Sutji Pratiwi1, Punagi Abdul Qadar1, Sidabutar Magdalena Octavia1,*, Perkasa Muh. Fadjar1 1Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty, Hasanuddin University, Makassar, Indonesia *Corresponding author: Magdalena Octavia Sidabutar, Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty, Hasanuddin University, Makassar, (90245) Indonesia, Email: lena.sidabutar@gmail.com
Online published on 23 December, 2019. Abstract Background Chronic tonsillitis can cause oxidative stress in the body. Objective The study aims to analyse plasma F2-Isoprostane level in chronic tonsillitis patients with and without risk of Obstructive Sleep Apnea Syndrome (OSAS). Materials and Method The design of this study is a clinical trial with pre and posttest control group. Sampling was done in Wahidin Sudirohusodo Hospital and Kassi-kassi Health Center, Makassar. In this study, the sample size of each group was 20 samples, consisting of chronic tonsillitis patients with OSAS risk in the first group and chronic tonsillitis patients without the risk of OSAS in second group. Both groups were given 1x1000 mg tablet of vitamin C for 14 days. Results The results of this study showed that there was no significant decrease in plasma F2-Isoprostane level in patient with chronic tonsillitis with and without risk of OSAS after administration of vitamin C. There was no significant difference in decreased of plasma F2-Isoprostane level in patients with chronic tonsillitis at risk of OSAS after the administration of vitamin C especially in chronic tonsillitis patients without OSAS risk. Conclusions There was no significant decrease in plasma F2-Isoprostane level in patient with chronic tonsillitis with and without risk of OSAS after administration of vitamin C. There was no significant difference in decreased of plasma F2-Isoprostane level in patients with chronic tonsillitis at risk of OSAS after administration of vitamin C especially in chronic tonsillitis patients without OSAS risk. Top Keywords Chronic Tonsillitis, OSAS, F2-Isoprostane, Vitamin C. Top |