Analysis of VDR Gene Expression and its Relationship with Bacterial Load in Typhoid Fever Patients Efendi Suradi1,2,*, Budu3, Hatta Mochammad4, Natsir Rosd iana5, Sriyanah Nour6, Maryunis7, Dwiyanti Ressy4 1Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan, Makassar, Indonesia 2Doctoral Students, Post Graduate School, Universitas Hasanuddin, Makassar, Indonesia 3Ophthalmology Department Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia 4Molecular Biology and Immunology Department Faculty of Medicine, Universitas Hasanuddin, Makassar 5Biochemistry Department Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia 6Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan, Makassar, Indonesia 7Public Hospital of Dr. Wahidin Sudirohusodo, Makassar, Indonesia *Corresponding author: Suradi Efendi1, E-mail: atolnurse@gmail.com, 08114111075
Online published on 23 December, 2019. Abstract In Indonesia, Typhoid must be taken seriously from various parties, because this disease is endemic and threatening public health. The vitamin D receptor gene (VDR) has been involved in modulation of susceptibility on inflammatory conditions including typhoid fever. This study aimed at investigating VDR genes expression and its relationship with bacterial load in typhoid fever patients This study used analytical survey design with cross-sectional approach, which focuses on Vitamin D Receptor (VDR) genes expression and its relationship with bacterial load in typhoid fever patients. The total sample was 55 sufferers. The statistical test used was Mann U Whitney with the confidence degree of 95% and value of α <0.05. All data were analyzed using the SPSS Version 21.0 program. The results showed the weak VDR gene expression (47.3%) and the strong one (52.75%), bacterial load was in the average at 43, 583, 636.36 ± 75, 649, 400.29, and there was relationship between VDR gene expression with bacterial load (p <0.001), which is the bacterial load tendency is higher in patients with weak VDR gene expression than the strong one. Strong VDR gene expression decreases bacterial load in cases of typhoid fever. Top Keywords VDR, bacterial load, typhoid fever. Top |