IL-18-607 Gene Polymorphisms in Iraqi Obese Patients Utba Nawal Mohammed* Department of Biology, College of Science, University of Baghdad, Al-Jaderia, Baghdad, Iraq *Corresponding Author: Nawal Mohammed Utba, Department of Biology, College of Science, University of Baghdad, Al-Jaderia, Baghdad, Iraq, Postal code 10071, Phone: +964 7901826834, Email: anooutba2014@yahoo.com
Online published on 23 December, 2019. Abstract Obesity is a serious medical illness where excess body fat has stored to the amount that it might have a negative impact on health. In general, people are regarded as obese when their body mass index is more than 30 kg/m2. A total of 100 Iraqi subjects from Wasit province were included in this study, 50 of them had normal weight with BMI less than 25 kg/cm2 and 50 obese with BMI more than 30kg/cm2. The polymorphisms were analyzed using single specific primer-polymerase chain reaction at the position-607 C\A (rs1946518). The genotype frequencies of normal weight group were in agreement with the Hardy-Weinberg equilibrium. While the genotype frequencies of obese group revealed significant variation (P> 0.05). In conclusion, IL-18-607 A alleles, CC, and CA genotypes showed positive association with the obesity in Iraqi Arab population or protection against it. Top Keywords Obesity, overweight, IL18 gene polymorphism, BMI, Iraq. Top |