Assessment of TNF-a, IL-17, IL-33, TGF-b, and Dopamine in Iraq Depressed Women with Chronic Toxoplasmosis Infection shaker Maha mahmood1, Alabassi Hazima Mossa2, Rahman Sabah A. Hameid A.1,* 1Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq 2Ibn AL-hytham Collage, Baghdad University, Baghdad, Iraq *Corresponding Author: Sabah A. Hameid A. Rahman, Ibn AL-hytham collage, Baghdad University, Baghdad, Iraq, Email: Sabahsabah@uomustansiriyah.edu.iq
Online published on 23 December, 2019. Abstract Background In Iraq, a high prevalence rate of Toxoplasma gondii infection was reported and data about correlation between this infection and major depressive disorders were documented. Therefore, the aim of current study was to evaluate the association between levels of parameters related to chronic toxoplasmosis infection and depression in Iraq women. Method In this study, 260 serum samples were collected from Iraqi women and divided into four groups as follow: G1 depressed women infected with toxoplasmosis, G2 women infected with toxoplasmosis but did not have depression, G3 depressed women without toxoplasmosis infection with toxoplasmosis, G4 apparently healthy persons. The following parameters were assessed TNF-a, IL-17, IL-33, TGF-b and dopamine. Statistical analysis was performed by using statistical analysis system. Results Data from current study revealed elevated levels of proinflammatory cytokines TNF-a, IL-33, IL17, as well as there was an increase in concentration of dopamine in G1. The mean ± SE levels for the three cytokines were (2444.69 ± 98.82, 3629.50 ± 61.10 and 1008.88 ± 36.35 pg/ml), respectively and the mean ± SE for dopamine was (387.33 ± 8.09 pg/ml), while TGF-b didn't show any elevation in its level in this group. Conclusion Elevated levels of both proinflammatory cytokines and dopamine in depressed women who had chronic infection of toxoplasmosis may reflect the effect of chronic infection that may alter the expression of dopamine which skew the immune response towered Th17 that affect the expression level of proinflammatory cytokines and neutrophils response. Top Keywords TNF-a, IL-17, IL-33, TGF-b, dopamine, toxoplasma infection, depression. Top |