Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 2419) Last page : ( 2422)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03223.6

AgNps as Antibacterial Agent Against Klebsiella pneumoniae Isolated from Wond Infection

Obaid Khamael H.*

University of al Zahraa for women, Kerbala, Iraq

*Corresponding Author: Khamael H. Obaid, University of al Zahraa for Women, Kerbala, Iraq, Email: pcr2000@yahoo.com

Online published on 23 December, 2019.

Abstract

One hundred wound swab samples were collected from wound patients who visited the Teaching Hospital wound unit, Hillah, Babylon province, Iraq. K. pneumoniae was identified morphologically and biochemically. Total of 10 (10%) from total samples exhibited positive culture for K. pneumoniae. Antibiotic susceptibility was tested for 12 antibiotics. K. pneumoniae isolates showed high resistance rates to penicillins including ampicillin, amoxicillin (100%) and piperacillin (90%). The present study indicated that resistance to β-lactamase inhibitors including amoxicillin-clavulanic acid, ampicillin-sulbactam and ticarcillin-clavulanic acid were 100%, 90% and 70% respectively. This investigation also indicated that K. pneumoniae had high rates of resistance to the third generation of cephalosporins including cefotaxime (80%) followed by ceftazidime (80%), ceftriaxone (80% (and Cefepime (60%(. During the study period, 4 (40%) isolates were found resistant to both imipenem and meropenem. Anti-bacterial activity of silver nanoparticles (AgNps) against K. pneumoniae displays excessive widespread spectrum antibacterial action against established bacteria with increased zone of inhibition diameter that is proportional with the increase in nanoparticle concentration. The (MIC of AgNps ranged from 50–100μg/ml and the MBC ranged from 100–200μg/ml.

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Keywords

Ag Nanoparticles, K. pneumonia, wound infection.

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