Toxic Effects of Sodium Benzoate on the Rat Testes Al-Ani Ban Thabit1, Al-Saadi Rana R.1,*, Wassef Hikmat Fakhri1 1High Institute of Infertility Diagnosis and ART's, Al Nahrain University, Baghdad, Iraq *Corresponding Author: Rana R. Al-Saadi, High Institute of Infertility Diagnosis and ART's, Al Nahrain University, Baghdad, Iraq, Email: drranaa2018@gmail.com
Online published on 23 December, 2019. Abstract Objective Humans are exposed to intricate combinations of chemicals in their food. Antioxidants are examples of these chemicals and used as food preservatives. Such chemicals are presented in the food to advance aroma, taste, and/or appearance and preserve decent qualities of food (antioxidants, preservatives) like sodium benzoate (NaB) which is commonly used as a food preservative. Aim of study This experiment intended to realize the sodium benzoate effects on certain hormonal and histological parameters on male rat reproductive system. Material and Method As a mammalian, model thirty mature albino male rats. Distributed these rats into three assemblies once tagging them in a 10 rat/group. The experimental groups (TG1 and TG2) were orally managed with sodium benzoate 400 and 800 mg/kg body weight throughout the 70 days of the experiment, control group (CG) was managed orally with purified water only. Post-anesthetic blood sampling from left ventricle was used for hormonal measurements. Result The statistical analysis illustrates a vital reduction in both seminal vesicles and testes masses (P < 0.05) in comparison with CG. Sperm parameters reveal a vital reduction in the means of both sperm motility and concentration in treated groups (TGs) (P < 0.05) in comparison with CG. Additionally, seminiferous tubules diameters, secondary and primary spermatocytes, and spermatids had an extremely substantial decrease, while increasing interstitial space when treated with sodium benzoate in comparison with the CG. While comparing the levels mean of the hormone in the CG, testosterone serum levels show vital (P < 0.05) reduction in TG1 and TG2. The verdicts proposes that sodium benzoate administration with (400 and 800 mg/kg body weight) for 70 days prompted destruction in the reproductive organs and cause harmless of the sperm parameters functions causing both hormonal and histological changes Top Keywords Sodium benzoate, rats, reproductive organs, testis. Top |