Evaluation of Salivary Melatonin and Periodontal Parameters in Type II Diabetic Patients with Chronic Periodontitis: A Comparative Study Hassan Rusul Subhi1,*, Salman Suzan Ali2 1Dentist in Department of Periodontology, College of Dentistry, University of Kufa, Iraq 2Assisstant Professor in Department of Periodontology, College of Dentistry, University of Baghdad, Iraq *Corresponding Author: Rusul Subhi Hassan, Dentist in Department of Periodontology, College of Dentistry, University of Kufa, Iraq, Email: rusul.sbhi1989@gmail.com
Online published on 23 December, 2019. Abstract Background Diabetes mellitus and periodontitis are complicated chronic disorders with an established bidirectional relationship. Melatonin (MT) is neuroendocrine hormone, synthetized by pineal gland. Melatonin act as anti-inflammatory and anti-oxidant, thus plays significant role in chronic periodontitis and diabetic mellitus. Aims of study to measure and compare salivary melatonin level and periodontal health status among study groups of the chronic periodontitis with and without type II diabetes mellitus and contrast their level with control group. Materials and Method Eighty males were selected for the examination, with an age range of (35–55) years. The participants were divided into four groups (each group 20 patients): two diabetic groups (type II): moderately and well controlled both of them with chronic periodontitis and two non-diabetic groups: one of them with chronic periodontitis and the other with healthy periodontium and systemically healthy. Unstimulated salivary samples were collected from all of subjects to measure salivary melatonin (pg/ml) by Enzyme-linked immunosorbent-assay technique. Clinical periodontal parameters included: plaque index, gingival index, probing pocket depth and clinical attachment level had been recorded for all subjects. Results The chronic periodontitis with moderately controlled type 2 diabetes mellitus group had worst periodontal health status. The lowest level of salivary melatonin was found in the non-diabetic patients with chronic periodontitis group (25.17) pg/ml. There was a weak connection between clinical periodontal parameters and salivary melatonin. Conclusion Patients with moderately controlled type 2 diabetic have more destruction of periodontal tissue than other groups. Salivary melatonin may be helpful biochemical marker for destruction of periodontal tissues and this will provide better chances in early diagnosis and management of diabetes and periodontal diseases. Top Keywords Melatonin, diabetes mellitus, chronic periodontitis, clinical periodontal parameters. Top |