Physiological and Behavioral Changes of Male Rats Following Social Isolation Stress During Early-Adolescence and Fluoxetine Exposure CHabuk Halla Abdul-Hadi1, Al-Saadi Haider Kamil Zaidan2, Al-Harbi Hussein Jasim1 1College of Science, University of Babylon, Hilla, Iraq 2Department of scholarships and cultural Relations, Ministry of Higher Education and Scientific Research, Baghdad, Iraq Online published on 23 December, 2019. Abstract Stress experiences during youth lead to abnormal behavior profile in adulthood, including an increase in aggression, depression and anxiety disorders in humans. The animals during early-adolescent period (PD 35) were divided into the following groups: Group 1-Control. Group II-social isolation stress for 42 days-Negative control. Group III-The animals were treated with 10 mg/kg of the fluoxetine for 21 days in combination with isolation stress for 21 days, all groups followed by behavioral studies, and assessed the biochemical effects of exposure to stress and stress with drug. The results showed there was significantly improvement in the open field test including significantly increased locomotor and exploratory activity with decreased anxiety and aggressive behavior after treatment with fluoxetine compared to stress group. The results were also noted significant increase in the levels of brain serotonin in stress with fluoxetine group compared to stress group, The results showed significantly decreased in levels of dopamine and monoamine oxidase A in brain tissue of rats treated with fluoxetine compared to stress group. While corticosterone, testosterone and LH levels in stress rats showed significantly increased compared to stress with fluoxetine group. Top Keywords Fluoxetine, isolation stress Serotonin, Dopamine, Testosterone, Aggressive behavior. Top |