Pharmacognostical Study and Antibacterial Activity of Cardio Active Glycoside of Iraqi Yellow Oleander (Thevetia Peruviana L.) Falih Hayder Yousif1,*, Nasser Noor Mohsen2, Jasiem Thamer Mouhi2 1Department of Basic Sciences, College of Dentistry, Mustansiriyah University, Baghdad, Iraq 2Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq *Corresponding Author: Hayder Yousif Falih, Department of Basic Sciences, College of Dentistry, Mustansiriyah University, Baghdad, Iraq, Email: Hayder.yousif2019@gmail.com
Online published on 23 December, 2019. Abstract Objective Thevetia peruviana consider from the toxic plants for all vertebrates because the major active constituents are cardio active glycosides and caused many poisoning for humans the toxins active consitiuent such as thevetin A and thevetin B. The aim of this study was isolation of the major active compound which found in the leaves of Iraqi plant which cultivated in Iraq environments and investigated the biological activity of it on different pathogenic bacteria. The plant anatomical results were reference to Anomocytic stomata type in the leaves, Unicellular unbranched covering of trichomes, fibers and starch present in the leaves of the T. peruviana plant. Which confirms that isolated compound from preparative TLC is thevetin. According to the results as shown in Pharmacognostical and phytochemical studies. The pathogenic bacteria which used for investigated the bioactivity of leaves extract of yellow oleander were E coli, pseudomonas aeruginosa, Streptococcus spp., Staphylococcus epidermidis, Enterococcus faecalis, Klebsiella pneumoniae and Staphylococcus aureus. The different concentrations of cardioactive glycosides extract from leaves (1000, 500, 250, 125, 63.5μg/ml) were found active for all microorganisms strain in concentration 1000 μg/ml while inactive in 63.5 μg/ml concentration exception Enterococcus faecalis effected in this concentration Top Keywords Thevetia peruviana leaves, phytochemical screening, Antibacterial activity. Top |