Correlation of Protein Tyrosine Kinase with Thyroid Hormones in Type 2 Diabetes Mellitus Patients and those with Diabetic Nephropathy Iraqi Patients Al-Khdhairi Zainab Mahdi Abed1, Ali Bushra H.1 1College of Education for Pure Sciences (Ibn-Al-Haitham), University of Baghdad, Iraq Online published on 8 March, 2019. Abstract Diabetes mellitus is a metabolic disorder categorized hyperglycemia resulting from defects in insulin secretion, insulin action or both. Protein tyrosine kinase (PTK) is an enzyme that catalyzes the transfer of phosphate groups from ATP to the tyrosine residues of many important proteins resulting in proteins phosphorylation. The aim of current study was to evaluate serum levels of protein tyrosine kinase enzyme and thyroid hormone (T3, T4and TSH) and to find the correlation between them in type 2 diabetes mellitus and diabetic nephropathy Iraqi patients. Methods: This study was conducted at The National Diabetes Center, Al-Mustansiriya University, Baghdad, Iraq and included 150 patients divided into three groups the first group included 50 Iraqi patients newly diagnosis with type 2 diabetic, as group2, the other group included 50 patients with diabetic nephropathy as group3, and the last group included 50 healthy subjects as controls. as group1. The period of time for collection of blood samples extended from July to October 2017. All patients were between 18 and 60 years old. Results The results of current study showed that the mean±SD levels of serum T3 in G3 was 1.77±0.19ng/mL and in G2 was 1.67±0.2ng/mL; whereas in G1 was 1.69±0.23ng/mL (P>0.05). On the other hand, the mean±SD levels of serum T4 were 8.99±0.58ng/mL, 8.84±0.69ng/mL and 8.55±0.81ng/mL in the G3, G2 and G1 groups, respectively, (P< 0.001). In addition, the mean±SD levels of serum TSH were 2.61±0.34μIU/ml, 2.5±0.31μIU/ml and 2.52±0.44μIU/ml in the three groups, respectively, (P< 0.001). Moreover, the mean serum levels of tyrosine kinase were 15.2ng/mL, 21.19ng/mL and 8.86ng/mL in the three groups, respectively, (P< 0.001). Correlation study revealed non-significant positive correlation between tyrosine kinase and T3 in G1 and G2 (r= +0.200, r= +0.068, respectively, (P>0.05) while non-significant negative correlation existed between tyrosine kinase and T3 in G3 (r =-0.154) (P>0.05). Non-significant negative correlation was observed between tyrosine kinase and T4 in G1(r=-0.014) (P>0.05). In addition, non-significant positive correlation was observed between tyrosine kinase and T4 in G2 and G3 (r =+0.178, r= +0.073, respectively) (P>0.05). Top Keywords Iraqi patients, diabetic, protein tyrosine kinase, Type 2 diabetes mellitus, diabetic nephropathy, thyroid hormones, TSH, protein tyrosine kinase. Top |