Determination of Immunological Markers associated with Celiac Disease in Basrah province AL-Hilfi Sufyan Abdul Rahman Abd Ali1,*, Shani Wafaa S.1 1Department of Biology, College of Science, University of Basrah, Basrah, Iraq *Corresponding author: Sufyan AbdulRahman Abd Ali AL-Hilfi. Department of Biology, College of Science, University of Basrah, Basrah, Iraq
Online published on 15 March, 2019. Abstract Present work designed to study the role of sHLA-G and some proinflammatory and anti-inflammatory cytokines in pathogenicity of Celiac disease. So 65 blood samples from Celiac patients and 24 healthy control were included in recent study. Sera of all studied groups (patients and control were enrolled in order to determining the level of sHLA-G, proinflammatory cytokines (TNF-α, IL-6) and anti-inflammatory cytokines (IL-10). In addition. Present data revealed that (39) or (23%) of patients with a family history with a significant differences (p≤0.05). In relation to immunological markers which studied in recent work the sHLA-G molecule in sera of patients showed a highly significant elevation (p≤0.001) in compared with control. In the case of inflammatory cytokines IL-6 and TNF-α were also recorded a highly significant and significant increasing (p≤0.016) and (p≤0.05) respectively in celiac patients in comparable to control. Present data related to anti-inflammatory cytokines IL-10 revealed a significant arising in patients in comparison with the control. Furthermore, significant statistical correlation was occurred between sHLA-G and TNF-α with TTG, whereas IL-6 and IL-10 not recorded any correlation with TTG Top Keywords TNF-α, HLA-G, Tissue inflammatory response, IL-10, IL-6, Celiac disease. Top |