The Role of Lewis Blood Type Molecules in Atopic Dermatitis Ali Khedhir Hassan1,*, Abdul Fatima Rammadan2, Subhi Hanan Tariq3 1Professor of Immunology and Microbiology, Mustansiriyah University, Baghdad, Iraq 2Microbiology, Ph. D, Department of Biology; College of Science; Mustansiriyah University, Baghdad, Iraq 3Microbiology, Ph. D, Department of Biology; Faculty of Health and Science; Koya University, Irbil, Iraq *Corresponding author: Khedhir Hassan Ali., Professor of Immunology and Microbiology, Mustansiriyah University, Baghdad, Iraq; E-mail: qetasyshah@gmail.com
Online published on 15 March, 2019. Abstract This study aims to find if there is an association between AD disease and Lewis blood groups phenotypes in addition, isolation and frequency of S. aureus from skin and stool were studied also. Fifty patients of male and female genders were enrolled beside, a similar proportion of genders were included in 45 healthy controls. Lewis phenotypes were identified in red blood cells using hemagglutination testing while S.aureus was isolated using conventional bacteriological procedures. Anti-S.aureus antibodies were evaluated by using ELISA. The results revealed increased Lea frequency of 70% compared to 24.4% in controls (Z-test, P=2.28×10−5, 95% Cl =0.256–0.655). On the other hand, there was a marked decrease in Leb frequency approaching 8% compared to 48.9% in the controls (Z-test, P=3×10−5, 95% Cl =0.223–0.594). Lea+b+ was doubled and there was no significant increase in Lea-b-. S.aureus were isolated from skin showed increased isolation frequency of patients 18% compared to nil isolation frequency of controls. Patients with AD of all Lewis blood types had increased in anti-S.aureus antibody titers compared to positive but low anti-bacterial antibody titers among controls. Top Keywords Lewis blood groups, atopic dermatitis, Staphylococcus aureus. Top |