Royal Jelly and Honey Ameliorates Cisplatin Induced Alterations in Biomarker Levels of Oxidative Stress in Kidney of Rat Bhalchandra Waykar1, Alqadhi Yahya Ali2 1Professor, Department of Zoology, Faculty of Science, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India 2Ph. D Researcher, Department of Zoology, Faculty of Science, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India Online published on 15 March, 2019. Abstract Background Cisplatin is one of the cytotoxic agents in the treatment of cancer and has side effects on kidney function. Honey and royal jelly are both natural antioxidant. Objective This study investigated the ameliorative role of honey and royal jelly against cisplatin induced biomarker levels of oxidative stress in rat kidney by measuring tissue biochemical and antioxidant parameters. Method Male wistar albino rats of approximate same age and weight were randomly divided into four groups. Group I: control group was given 0.9% saline. Group II; cisplatin (7mg/kg/day) was injected intraperitoneally for 15 days. Group III; honey with royal jelly (500 mg/kg/day of honey and 100mg/kg/day of royal jelly) was fed orally daily for 15 days. Group VI; cisplatin (7mg/kg/day) was injected and honey with royal jelly (500mg/kg/day of honey and 100mg/kg/day of royal jelly) were fed orally daily for 15 days. Results Cisplatin caused a significant increase in the level of malondialdehyde (MDA) in kidney tissue. The level of glutathione (GSH) and activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were significantly decreased in (G, II). Supplementation of honey and royal jelly to rat (G, III) caused non-significant decreased in the level of malondialdehyde (MDA) in kidney tissue. In contrast, the level of glutathione (GSH) and activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (G, Px) activities were non-significantly increased compare to control. In (G, IV), honey and royal jelly in cisplatin association, there was improvement in biomarker levels of oxidative stress. Conclusion Oral administration of honey and royal jelly ameliorated the toxic effects and provided substantial protection against cisplatin-induced nephrotoxicity. Top Keywords Antioxidants, rat, kidney, cisplatin, honey, royal jelly, oxidative stress. Top |