Effect of Bone Morphogenetic Protein-4 on the Expression of BMP-7In Bone Repair Al-Hijazi Athraa Y.1,*, Al-Mahammadawy Abdul Karim A2, Al-Rifae Imad K. Abbas1, Khashman Basim M3, Izzat Alaa Wael4 1Al-Mustaqbal University College, Dentistry Department, Babel, Iraq 2College of Dentistry, Mustansiriya University, Baghdad, Iraq 3National Cancer Research Center, Baghdad 4College of Dentistry, University of Baghdad *Corresponding Author: Athraa al-hijazi Al-Mustaqbal University College, Dentistry Department, Babel, Iraq Email: athraayms@yahoo.com
Online published on 20 March, 2019. Abstract Background BMPs play important roles in normal bone development and regulation of bone repair by their ability to stimulate osteogenesis, cell differentiation and apposition of bone matrix. Aim of study to find role for the application of BMP4 in bone defect with expression of BMP7 by newly formed bone. Materials and Method Twenty male Wistar rats were used to create a drill-hole injury (3mm) bone defects in femur, one in the left side represented the control, while the right side represented the experimental. The study groups include: Bone repair was examined histologyically and immunohistochemically for the expression of BMP7 at the postoperative periods 14 and 28 day. Result Show increased bone formation with proceeding time postoperatively for both study groups, although experimental group illustrates more bone apposition that filled the defect at 28 day. Moreover intense positive expression of BMP7 by stromal and bone cells were illustrated in experimental group with high significant differences in comparisum to control. Conclusions BMP4 seems to play an important role in bone repair; induced expression of BMP7 correlates with the bone repair outcome. Top Keywords Bone morphogenic proteins, bone repair, bone signals, bone cell, BMP7, osteogenesis. Top |