Role of Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Early Staging of Bladder Cancer Abd-Kadhim Mohammed1, Hussein Mohammad Abd-Alrida2, Fawzi Hayder Adnan3,* 1Consultant Radiologist, College of Medicine, Al-Nahrain University, Baghdad, Iraq 2Radiologist, Oncology Teaching Hospital, 3Clinical Pharmacist, Baghdad Medical City, Baghdad, Iraq *Corresponding Author: Hayder Adnan Fawzi Clinical Pharmacist, Baghdad Medical City, Baghdad, Iraq, Email: hayder.adnan2010@gmail.com
Online published on 20 March, 2019. Abstract Objective study the role of Dynamic contrast-enhanced (DCE), and Diffusion-weighted (DWI) MRI for preoperative early staging of urinary bladder cancer and compare their diagnostic accuracy with histopathological diagnosis. Materials and Method Thirty-seven patients with bladder cancer included in this study. All patients underwent Magnetic Resonance Imaging (MRI) on a 1.5-T scanner. MR images were evaluated and assigned a stage which compared with the histopathological staging depending on transurethral resection of bladder tumor (TURBT). Results There was substantial agreement between DCE-and DWI-MRI for T staging (kappa = 0.943, p <0.001), both MRI modalities had similar specificity for diagnosing stage T1 bladder CA with DWI offered slightly higher sensitivity (SN), positive predictive value (PPV), negative predictive values (NPV) and accuracy. Both MRI modalities show fair specificity for stage T2 with DWI offered slightly higher specificity and similar sensitivity for both with good accuracy. Conclusion MRI is an excellent modality for preoperative early staging as well as grading of the bladder cancer. Both Diffusion-weighted MR imaging and dynamic contrast-enhanced MRI offer excellent agreement for T-staging of bladder cancer with DWI as the preferred modality without the use of contrast media. Top Keywords Bladder cancer, diffusion-weighted, dynamic contrast-enhanced. MRI, transurethral resection. Top |