Pharmacovigilance Study of Antituberculosis Drug Regimens in Adult Patients Farida Yeni1,*, Sholikhah Anggun Nurus1, Niruri Rasmaya1 1Department Pharmacy, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia *Corresponding Author: Yeni Farida, Department Pharmacy, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Jl. Ir. Soetami 36 A Kentingan, Surakarta, 57126, Email: yenifarida@staff.uns.ac.id
Online published on 20 March, 2019. Abstract The success of pulmonary tuberculosis (TB) treatment in Indonesia was 81, 3%. Meanwhile, this number has been not reached the WHO target number of 85%. It was because patients experiencing Adverse Drug Reaction (ADRs) of antituberculosis drugs. Therefore, the government launched a pharmacovigilance program to monitor the ADRs of antituberculosis drugs to improve successful treatment. This study aimed to observe regimens of antituberculosis drug that often caused ADRs and the number event of ADRs. It was non-experimental numerical and analytical descriptive that conducted in outpatient Installation one of Hospital in Klaten, Central Java, Indonesia. Data were collected by interviewing and observing the patients’ medical records for two months starting from January to February 2018. The sample was obtained by using purposive sampling method. Then, the data were analyzed by the Liverpool algorithm that interpreted in 4 scales: unlikely, possible, probable, and definite. This study focused on 30 patients, which 23 patients with positive smear and seven patients with negative smear tuberculosis. The result showed that Fix Dose Combination (FDC) of rifampicin, isoniazid, pyrazinamide, ethambutol (RHZE) regimen was the most causing side effects. The number of ADRs were 3–7 in one patient. The most common side effects were reddish urine (90, 74%), nausea (90, 74%), vomiting (83, 33%), shortness of breath (70, 37%), and dizziness (22, 22%). Almost all antituberculosis drug regimens caused ADRs. Top Keywords Antituberculosis Drugs, Liverpool Algorithm, Pharmacovigilance. Top |