Comparative Study of CMC 0.5% Eye Drops versus Combination of.05% Cyclosporin Ophthalmic Emulsion and 0.5% CMC Eye Drops in Dry Eye Disorders Agarwal Prerana1,*, Pandey D.J.2 1Assistant Professor, Department of Ophthalmology, Saraswathi Institute of Medical Sciences, Hapur, U.P (India) 2Professor, Department of Ophthalmology, Saraswathi Institute of Medical Sciences, Hapur, U.P (India) *Corrosponding author-Dr. Prerana Agarwal, MS, Assistant Professor, Department of Ophthalmology, Saraswathi Institute of Medical Sciences, Hapur, U.P (india) Email: docprernaagarwal@gmail.com
Online published on 6 April, 2019. Abstract Background Dry eye disease is a common disorder provoking changes in tear film and ocular surface. Untreated dry eye could cause ocular infections, corneal ulcer and blindness. Only a few drugs are authorized so far for the treatment of dry eye disease and the possibilities of evolution in this sector are immense. Objectives Compare efficacy of carboxy methyl cellulose.5% eye drops with combination of 0.5% carboxy methyl cellulose eye drops and.05% cyclosporin ophthalmic emulsion for treatment of dry eyes. Material and Method 40 patient presenting with dry were selected randomly. They were divided into 2 groups. Group I received CMC.5% eye drops four times a day and group II received.05% Cyclosporin ophthalmic emulsion two times daily and.5% CMC eye drops 4times a day. All patients were evaluated on day 0, 2 weeks, 1 month, 3 month and 6 month for relief in ocular symptoms and diagnostic dry eye tests. Results The mean age in group I was 39.72 ± 6.85 years and in group II was 40.2 ± 5.28 years. Ocular discomfort, dryness and tearing were seen in all the cases. Comparison of different parameters after six months of treatment between group I and II showed that the comparision of net score in two groups is statistically significant(p < 0.05). Conclusions There was statistically significant difference between the outcome of two groups. Group 2 patients who used combination of cyclosporin0.05% ophthalmic emulsion two times daily along with CMC 0.5% eye drops 4 times a day were better relieved as compared to patients in group 1 who used 0.5% CMC eye drops four times daily for treatment of dry eyes Top Keywords Carboxymethylcellulose, Cyclosporine, Dry eye. Top |