Effective Usage of Exhaled Volatile Organic Compounds in Disease Diagnosis: A Comprehensive Review Karthick G.S.1, Pankajavalli P.B.2 1Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, India 2Assistant Professor, Bharathiar University, Coimbatore, Tamil Nadu, India Online published on 6 April, 2019. Abstract Aim The potentiality of exhaled biomarkers like volatile organic compounds [VOC's] are gaining more importance and assists in accurate diagnosis of diseases. The main aim of this article is to reveal the existing methodologies on evaluating the exhaled VOC's with respect to the diagnosis of various diseases which includes asthma, chronic obstructive pulmonary disease [COPD], lung cancer, chronic kidney disease [CKD] and acute respiratory distress syndrome [ARDS]. Literature Source This comprehensive review was conducted based on the literature identified in PubMed, PsycINFO, Medline Plus and other various search results. This article explores the diagnosing of diseases like asthma, COPD, lung cancer, CKD and ARDS via monitoring the VOC's in exhaled breath. Findings and Discussions From the records identified, twenty two studies were found to be eligible for comprehensive review which includes 1, 223 healthy subjects and 1, 206 patients. The non-invasive techniques used for collecting and analyzing the VOC's in exhaled breath and its outcomes were mined. This review seamlessly discloses the differences between the healthy subjects and patients with severe disease. Conclusion It is found that exhaled breath VOC's summary of humans are potential enough to correctly diagnose multiple diseases. The findings has recognized various standardization challenges and proof is required before adapting this practice into clinical diagnosis. Top Keywords Exhaled breath, VOC's, COPD, CKD, ARDS, Asthma, Pulmonary diseases, Biomarkers. Top |