Irisin, Resistin and 25-Hydroxyvitamin D in Iraqi Obese and Non-Obese Type 2 Diabetic Patients Zamil Gumar O1, Mahmmod Halla G2, Saleh Basil O3,* 1Clinical Biochemistry, Ibn Al-Baladi Children's and Women's Hospital, Ministry of Health, Baghdad, Iraq 2Clinical Biochemistry, Department of Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq 3PhD, Clinical Biochemistry, Department of Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq *Correspondence author: Basil O Saleh, Telephone: +9647904407625, E-mail: basil_omsal@yahoo.com
Online published on 6 April, 2019. Abstract Objective Evaluate the serum levels of irisin, resistin, and vitamin D in a population of Iraqi obese diabetic men and to compare non-obese diabetic men. Methods A case-control study, carried out from July 2017 to January 2018, and included 160 men; 80 patients with type 2 diabetes mellitus (DM) and 80 aged-and BMI matched apparently healthy men. The Subjects subdivided according to their BMI into; obese, overweight and normoweight. Investigations included serum measurements of fasting serum glucose (FSG) and lipid profile, 25-Hydroxyvitamin D, resistin, irisin and insulin. Results Serum resistin levels and 25-hydroxyvitamin D did not differ significantly among groups of diabetic men and healthy men with respect to their obesity. Serum irisin concentrations were significantly decreased in diabetic obese when compared with that of healthy obese. While, the mean values of serum irisin of diabetic overweight and diabetic normoweight were higher than those of healthy overweight and normoweight, but did not reach the significant level. The results also showed that there was significant positive correlation between serum 25-hydroxyvitamin D levels and irisin concentrations in diabetic obese group (r= 0.398, P<0.022). Conclusion The present study suggested the significant role of irisin myokine in pathogenesis of diabetes mellitus type 2, while that of resistin and vitamin D need to be evaluated in one more large study. Obesity may have an important effect on blood levels of irisin and vitamin D. Top Keywords Diabetes mellitus, obesity, 25-hydroxyvitamin D, Irisin, resistin. Top |