Prognostic Role of ki-67 Immunohistochemistry in Soft Tissue Sarcoma: Review and Meta-Analysis Al-salih Aws Rassul Hussein1,*, Al-Shaibany Raad Jawad Kadhim2 1Assistant professor, FICMS (pathology), University of Al-Qadisiyah, College of Medicine, Department of Pathology and Forensic Medicine, Al-Diwaniyah Province Iraq 2Assistant Professor, FICMS (orthopedic), University of Al-Qadisiyah, College of Medicine, Department of Surgery, Al-Diwaniyah Province Iraq *Corresponding author: Aws Rassul Hussein Al-salih. Assistant Professor, FICMS (Pathology), University of Al-Qadisiyah, College of Medicine, Department of Pathology and Forensic Medicine, Al-Diwaniyah Province Iraq.
Online published on 6 April, 2019. Abstract Malignant soft tissue tumors or soft tissue sarcomas accounts for less than one percent of all malignant neoplasms affecting mankind; however, they include more than 50 types of mesenchymal tumors based on histological. The number of articles dealing with the subject of Ki-67 immunohistocehmistry in soft tissue sarcoma is relatively great since the administration of this marker in the field of surgical pathology; however, the big picture about the definite role of Ki-67 in soft tissue sarcoma requires the collection of these data in a single meta-analysis study. Thus, the aim of present study is to review the role of Ki-67 immunohistochemical expression in soft tissue sarcoma using meta-analysis design Google search engine was used and the following key words were used in a variety of combination: Ki-67, immunohistochemistry, soft tissue sarcoma, prognosis, grading, role of and survival. Inclusion criteria included any article dealing with the immunohistochemical role of Ki-67 in soft tissue sarcoma of any histological subtype or as a group In the present study we found that moderate and strong ki-67 expression is associated with < 50% 5 years survival, whereas, weak ki-67 expression is associated with > 50% survival. Top Keywords Ki-67, immunohistochemistry, soft tissue sarcoma, meta-analysis. Top |