FTO rs17817449 Gene Polymorphism as a Predictor for Maternal Obesity in Iraqi Pregnant Women Al-Ogaidi Shahla O.1,*, Abdulsattar Sura A.2, Al-Dulaimi Hameed M. J.3 1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq 2College of Medicine, Mustansiriyah University, Baghdad, Iraq 3College of Biotechnology, Al-Nahrain University, Baghdad, Iraq *Corresponding author: Shahla O. Al-Ogaidi, Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq, E-mail: shahla_aleqdei@yahoo.com
Online published on 6 April, 2019. Abstract Background The prevalence of overweight and obesity is rising worldwide, particularly, among women of reproductive age. FTO gene is one of these genes that increase susceptibility to obesity. The goal of this study was to analyze the association between the FTO rs17817449 SNP with maternal obesity and metabolic biomarkers in Iraqi pregnant women. Women were divided into 2 groups according to BMI: Overweight/Obese (BMI> 24.9) and control (BMI<24.9). Genotyping of FTO rs17817449 SNP was determined by tetra-primer ARMS-PCR. Metabolic biomarkers included fasting glucose FG, glycated hemoglobin HbA1c, lipid profile, fasting insulin, leptin LEP, leptin receptor LEPR, LEP/LEPR ratio, and HOMA-IR. Statistical analysis revealed that participants with the homozygous mutant (GG) genotype significantly increases the odds of being overweight/obese (adjusted OR: 3.972, CI 95% 1.209–13.048, P= 0.023) and each copy of risk allele (G) is associated with overweight/obese (OR: 2.6258, 95% CI: 1.4025–4.916, P=0.0026) FTO rs17817449 SNP was associated only with higher maternal BMI, TC, LDL-C and LEP/LEPR among the study group. While among overweight/obese group, FTO rs17817449 SNP only associated with increased TC, LDL levels, and BMI Top Keywords Body mass index, FTO gene, Pregnancy, Maternal obesity, Insulin, Leptin receptor, Leptin, Tetra-primer ARMS-PCR. Top |